By the Banger Labs Research Team · Updated June 2026
What is Sermorelin?
Sermorelin (GRF(1-29)-NH2) is a synthetic peptide consisting of the first 29 amino acids of endogenous human growth hormone-releasing hormone, which is itself a 44-residue hypothalamic peptide. This 1-29 segment is the shortest fragment reported to retain the full intrinsic GHRH activity of the parent molecule, and it is classified as a GHRH analog / growth hormone secretagogue. It is described here strictly for research and educational reference.
How Sermorelin is studied
In published pharmacology, sermorelin binds the growth hormone-releasing hormone receptor (GHRHR), a G-protein-coupled receptor on anterior pituitary somatotroph cells, where receptor activation is coupled to adenylate cyclase and cAMP/PKA signaling. In research models this is characterized as a secretagogue action that prompts the pituitary to release its own (endogenous) growth hormone in a pulsatile manner, rather than supplying exogenous growth hormone, and it remains subject to negative feedback by somatostatin. Reported pharmacokinetics describe a short circulating half-life (~11-12 minutes) and rapid degradation, including dipeptidyl peptidase-IV (DPP-IV) cleavage.
Research areas
- Studied as a tool compound in neuroendocrine growth-hormone-axis research models
- Investigated in GHRH-receptor (GHRHR) pharmacology and somatotroph cAMP/PKA signaling studies
- Used in research characterizing pulsatile endogenous growth hormone secretion and somatostatin feedback
- Examined in peptide pharmacokinetic and metabolic-stability research (e.g., DPP-IV degradation, plasma clearance)
- Referenced in comparative growth hormone secretagogue research and analog structure-activity studies
These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.
Sermorelin specifications
Handling & quality
Sermorelin is held to a ≥ 99% HPLC purity standard with a Certificate of Analysis available per batch. Reconstitute with bacteriostatic water and store refrigerated; handle strictly for research. See reconstitution & storage.
Frequently asked questions
What is Sermorelin?
Sermorelin (GRF(1-29)-NH2) is a synthetic peptide consisting of the first 29 amino acids of endogenous human growth hormone-releasing hormone, which is itself a 44-residue hypothalamic peptide. This 1-29 segment is the shortest fragment reported to retain the full intrinsic GHRH activity of the parent molecule, and it is classified as a GHRH analog / growth hormone secretagogue. It is described here strictly for research and educational reference.
Is Sermorelin research use only?
Yes. Sermorelin is supplied strictly for laboratory research — not for human or veterinary use, and not as a drug, food, or supplement.
Does Banger Labs provide a COA for Sermorelin?
Yes — a Certificate of Analysis (HPLC purity + mass-spec identity) is available per batch on request. See the COA Library.
References
- Sermorelin — Wikipedia (encyclopedic summary with referenced primary literature)
- Pharmacokinetics of growth hormone-releasing hormone(1-29)-NH2 and stimulation of growth hormone secretion in healthy subjects after intravenous or intranasal administration — PubMed (primary research article)
- Testing with growth hormone-releasing factor (GRF(1-29)NH2) and somatomedin C measurements for the evaluation of growth hormone deficiency — PubMed (primary research article)
Sources are provided for scientific reference and describe laboratory/preclinical research; they do not constitute medical advice or efficacy claims.
Shop Sermorelin & related research peptides
By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Educational information, not medical advice.