By the Banger Labs Research Team · Updated June 2026
What is HGH Fragment 176-191?
HGH Fragment 176-191 is a synthetic peptide that reproduces the C-terminal amino acid sequence (residues 176-191) of the human growth hormone (hGH) polypeptide. It belongs to the class of growth-hormone-derived fragment peptides; a closely related Tyr-modified analog of this region has been described in the literature as AOD9604. As a fragment, it lacks the full hGH structure and the regions associated with growth-hormone-receptor binding.
How HGH Fragment 176-191 is studied
In preclinical models, C-terminal hGH fragments of this region have been investigated for effects on adipose-tissue lipid metabolism, including reported antilipogenic activity (reduced de novo fat synthesis) and modulation of lipolytic pathways. Rodent studies of the related fragment reported changes correlating with beta-3 adrenergic receptor (β3-AR) RNA expression, and effects differed in β3-AR knockout models, implicating that pathway. Reported research observations indicate these fragments act on lipid metabolism in models without the IGF-1 elevation characteristic of full-length growth hormone, consistent with not engaging the growth-hormone receptor in the same manner.
Research areas
- Studied in in vitro adipocyte and adipose-tissue models examining lipid metabolism
- Investigated in rodent models for its relationship to beta-3 adrenergic receptor (β3-AR) expression and lipid pathways
- Examined in preclinical work on inhibition of de novo lipogenesis (antilipogenic activity)
- Used as a structure-activity research tool to localize the lipid-metabolism-active domain within the hGH C-terminus
- Studied as a research model for separating lipid-metabolism-related activity from the IGF-1 response associated with full-length growth hormone
These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.
HGH Fragment 176-191 specifications
Handling & quality
HGH Fragment 176-191 is held to a ≥ 99% HPLC purity standard with a Certificate of Analysis available per batch. Reconstitute with bacteriostatic water and store refrigerated; handle strictly for research. See reconstitution & storage.
Frequently asked questions
What is HGH Fragment 176-191?
HGH Fragment 176-191 is a synthetic peptide that reproduces the C-terminal amino acid sequence (residues 176-191) of the human growth hormone (hGH) polypeptide. It belongs to the class of growth-hormone-derived fragment peptides; a closely related Tyr-modified analog of this region has been described in the literature as AOD9604. As a fragment, it lacks the full hGH structure and the regions associated with growth-hormone-receptor binding.
Is HGH Fragment 176-191 research use only?
Yes. HGH Fragment 176-191 is supplied strictly for laboratory research — not for human or veterinary use, and not as a drug, food, or supplement.
Does Banger Labs provide a COA for HGH Fragment 176-191?
Yes — a Certificate of Analysis (HPLC purity + mass-spec identity) is available per batch on request. See the COA Library.
References
- Wu Z, Ng FM. Antilipogenic action of synthetic C-terminal sequence 177-191 of human growth hormone. Biochem Mol Biol Int. 1993;30(1):187-96. — PubMed (NCBI)
- AOD9604 (Tyr-modified hGH 176-191 fragment) — overview of structure and class — Wikipedia (reference overview)
Sources are provided for scientific reference and describe laboratory/preclinical research; they do not constitute medical advice or efficacy claims.
Shop HGH Fragment 176-191 & related research peptides
By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Educational information, not medical advice.