By the Banger Labs Research Team · Updated June 2026
What is Hexarelin?
Hexarelin (also known as examorelin) is a synthetic six-amino-acid peptide with the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, derived from the parent growth hormone-releasing peptide GHRP-6 by substitution of the position-2 D-tryptophan with its 2-methyl derivative. It belongs to the growth hormone secretagogue (GHS) class of research peptides. This brief is provided for research-use-only, educational purposes and makes no therapeutic, efficacy, or human-use claims.
How Hexarelin is studied
In preclinical and in vitro studies, hexarelin acts as an agonist of the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein-coupled receptor expressed in the pituitary, hypothalamus, and various peripheral tissues, with signaling reported through phospholipase C and intracellular calcium mobilization. Research reports describe stimulation of pituitary growth hormone release via direct pituitary action and via hypothalamic mechanisms acting alongside GHRH in animal models. Studies also report binding to the scavenger receptor CD36 in cardiac and peripheral tissues, a pathway investigated independently of the GH axis.
Research areas
- Investigated in animal and in vitro models as a tool compound for growth hormone secretagogue receptor (GHS-R1a) signaling and pituitary GH-release pathways
- Studied in rodent models examining GHS-R1a and CD36 receptor binding and tissue distribution
- Examined in preclinical cardiomyocyte and ischemia/reperfusion research models exploring CD36-associated and IL-1 signaling pathways
- Used in research characterizing receptor regulation (e.g., GHS-R1a mRNA expression) and GHRH interaction in rats
- Explored in preclinical metabolic-research models (e.g., lipid metabolism endpoints in insulin-resistant mice)
These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.
Hexarelin specifications
Handling & quality
Hexarelin is held to a ≥ 99% HPLC purity standard with a Certificate of Analysis available per batch. Reconstitute with bacteriostatic water and store refrigerated; handle strictly for research. See reconstitution & storage.
Frequently asked questions
What is Hexarelin?
Hexarelin (also known as examorelin) is a synthetic six-amino-acid peptide with the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, derived from the parent growth hormone-releasing peptide GHRP-6 by substitution of the position-2 D-tryptophan with its 2-methyl derivative. It belongs to the growth hormone secretagogue (GHS) class of research peptides. This brief is provided for research-use-only, educational purposes and makes no therapeutic, efficacy, or human-use claims.
Is Hexarelin research use only?
Yes. Hexarelin is supplied strictly for laboratory research — not for human or veterinary use, and not as a drug, food, or supplement.
Does Banger Labs provide a COA for Hexarelin?
Yes — a Certificate of Analysis (HPLC purity + mass-spec identity) is available per batch on request. See the COA Library.
References
- Mechanism of action of Hexarelin. I. Growth hormone-releasing activity in the rat — PubMed (Eur J Endocrinol, 1996)
- GH-releasing activity of Hexarelin, a new growth hormone releasing peptide, in infant and adult rats — PubMed (Life Sci, 1994)
- The Growth Hormone Secretagogue Hexarelin Protects Rat Cardiomyocytes From in vivo Ischemia/Reperfusion Injury Through Interleukin-1 Signaling Pathway — PubMed (Int Heart J, 2017)
- Hexarelin, a Growth Hormone Secretagogue, affects Lipid Metabolic Aberrations in Nonobese Insulin-Resistant Male MKR Mice — PMC (Endocrinology, 2017)
Sources are provided for scientific reference and describe laboratory/preclinical research; they do not constitute medical advice or efficacy claims.
Shop Hexarelin & related research peptides
By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Educational information, not medical advice.