By the Banger Labs Research Team · Updated June 2026
What is ARA-290?
ARA-290, also designated cibinetide, is a synthetic linear 11-amino-acid peptide engineered from the helix-B surface domain of the human erythropoietin (EPO) molecule. Its reported sequence is pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. It belongs to the class of non-erythropoietic, EPO-derived tissue-protective peptides used as research reagents.
How ARA-290 is studied
In published preclinical literature, ARA-290 is described as a selective agonist of the “innate repair receptor” (IRR), a heterocomplex composed of the EPO receptor and the beta-common receptor (CD131). Because its sequence is restricted to the helix-B surface domain, it is reported to engage this receptor complex while not binding the homodimeric erythropoietic receptor, and the IRR is described as upregulated locally on stressed or injured tissue rather than constitutively expressed.
Research areas
- Studied in research literature on small nerve fiber loss and neuropathic signaling, including sarcoidosis-associated research
- Studied as a non-erythropoietic, tissue-protective EPO-derived peptide in research on cytoprotection and inflammatory signaling
- Examined in metabolic and insulin-resistance research
- Evaluated in laboratory models of tissue injury and repair signaling (e.g., ischemic and metabolic injury models)
- Used as a research tool to probe innate repair receptor (EPOR/CD131) biology
These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.
ARA-290 specifications
Handling & quality
ARA-290 is held to a ≥ 99% HPLC purity standard with a Certificate of Analysis available per batch. Reconstitute with bacteriostatic water and store refrigerated; handle strictly for research. See reconstitution & storage.
Frequently asked questions
What is ARA-290?
ARA-290, also designated cibinetide, is a synthetic linear 11-amino-acid peptide engineered from the helix-B surface domain of the human erythropoietin (EPO) molecule. Its reported sequence is pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser. It belongs to the class of non-erythropoietic, EPO-derived tissue-protective peptides used as research reagents.
Is ARA-290 research use only?
Yes. ARA-290 is supplied strictly for laboratory research — not for human or veterinary use, and not as a drug, food, or supplement.
Does Banger Labs provide a COA for ARA-290?
Yes — a Certificate of Analysis (HPLC purity + mass-spec identity) is available per batch on request. See the COA Library.
References
- Safety and Efficacy of ARA 290 in Sarcoidosis Patients with Symptoms of Small Fiber Neuropathy: A Randomized, Double-Blind Pilot Study — Molecular Medicine (PMC)
- ARA 290 affects Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Increases Corneal Nerve Fiber Density — Molecular Medicine (PMC)
- ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, affects Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes — Molecular Medicine (PMC)
Sources are provided for scientific reference and describe laboratory/preclinical research; they do not constitute medical advice or efficacy claims.
Shop ARA-290 & related research peptides
By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Educational information, not medical advice.