By the Banger Labs Research Team · Updated June 2026
What is Adipotide?
Adipotide (also designated prohibitin-targeting peptide 1 / FTPP) is a synthetic peptidomimetic with the sequence CKGGRAKDC-GG-D(KLAKLAK)2, joining a cyclic vascular-homing motif to a proapoptotic moiety. It was first described by Kolonin and colleagues (2004) and is characterized in the literature strictly as a preclinical research compound, not an approved drug.
How Adipotide is studied
In published animal-model studies, the cyclic CKGGRAKDC domain is reported to bind a prohibitin / annexin A2 (ANXA2) receptor pair described on the endothelial cell surface of blood vessels supplying white adipose tissue. Following receptor-mediated internalization, the appended D(KLAKLAK)2 amphipathic domain is described as disrupting mitochondrial membranes and triggering apoptosis in those targeted endothelial cells. This mechanism has been characterized in rodent and non-human primate research models only.
Research areas
- Studied in preclinical rodent models as a probe of white adipose tissue vascular targeting
- Investigated in non-human primate research models examining adipose-vascular targeting
- Used as a research tool to study endothelial prohibitin / annexin A2 (ANXA2) receptor biology
- Examined in research on targeted (vascular-homing) proapoptotic peptide delivery
- Referenced in preclinical safety-signal research, including reported renal/nephrotoxicity observations
These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.
Adipotide specifications
Handling & quality
Adipotide is held to a ≥ 99% HPLC purity standard with a Certificate of Analysis available per batch. Reconstitute with bacteriostatic water and store refrigerated; handle strictly for research. See reconstitution & storage.
Frequently asked questions
What is Adipotide?
Adipotide (also designated prohibitin-targeting peptide 1 / FTPP) is a synthetic peptidomimetic with the sequence CKGGRAKDC-GG-D(KLAKLAK)2, joining a cyclic vascular-homing motif to a proapoptotic moiety. It was first described by Kolonin and colleagues (2004) and is characterized in the literature strictly as a preclinical research compound, not an approved drug.
Is Adipotide research use only?
Yes. Adipotide is supplied strictly for laboratory research — not for human or veterinary use, and not as a drug, food, or supplement.
Does Banger Labs provide a COA for Adipotide?
Yes — a Certificate of Analysis (HPLC purity + mass-spec identity) is available per batch on request. See the COA Library.
References
- Reversal of obesity by targeted ablation of adipose tissue — Kolonin et al., Nature Medicine 2004 (PMID 15133506)
- A Peptidomimetic Targeting White Fat Causes body-weight research and Improved Insulin Resistance in Obese Monkeys — Barnhart et al., Science Translational Medicine 2011 (PMID 22072637, PMCID PMC3666164)
- Prohibitin-targeting peptide 1 — Wikipedia (overview/structure reference)
Sources are provided for scientific reference and describe laboratory/preclinical research; they do not constitute medical advice or efficacy claims.
Shop Adipotide & related research peptides
By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Educational information, not medical advice.