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5-Amino-1MQ: Research Overview — Mechanism, Research Areas & References

By the Banger Labs Research Team · Updated June 2026

5-Amino-1MQ research peptide

Short answer: 5-Amino-1MQ (5-amino-1-methylquinolinium) is a synthetic small-molecule research compound studied in preclinical models as a selective, membrane-permeable inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). It is offered strictly for laboratory research use only and is not approved for human or veterinary use.

What is 5-Amino-1MQ?

5-Amino-1MQ is a synthetic small molecule built on a methylquinolinium (quinoline-derived) scaffold; it is a chemical entity, not a peptide. It was characterized in the published literature as a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). It is described and supplied as a research-use-only reference/tool compound and has no approved human therapeutic status.

5-Amino-1MQ — molecular structure (research illustration)

How 5-Amino-1MQ is studied

NNMT catalyzes transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine, a reaction that draws on the nicotinamide/NAD+ salvage pathway and the SAM methyl-donor pool. In published preclinical cell work, 5-Amino-1MQ inhibition of NNMT was associated with reduced intracellular 1-MNA and increased intracellular NAD+ and SAM. These observations are mechanistic findings in laboratory models only and do not constitute evidence of any human effect.

5-Amino-1MQ — receptor & cell-signaling research illustration

Research areas

  • Investigated as a chemical-biology tool compound for probing NNMT enzyme activity in vitro
  • Studied in cultured adipocyte models for effects on NAD+/SAM metabolite levels and lipid accumulation during differentiation
  • Used in rodent (diet-induced obesity) models as a research probe of NNMT-related energy metabolism
  • Examined in the context of NAD+ salvage-pathway and SAM methyl-cycle biology research
  • Referenced in medicinal-chemistry literature on quinoline-derived NNMT inhibitor design

These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.

5-Amino-1MQ research in a laboratory setting

5-Amino-1MQ specifications

Class Synthetic small-molecule (methylquinolinium scaffold; quaternary ammonium); NNMT enzyme inhibitor — not a peptide
Form Lyophilized powder (reconstitute with bacteriostatic water)
Purity standard ≥ 99% HPLC
Certificate of Analysis Available per batch on request
Use Research use only — not for human or veterinary use

Handling & quality

5-Amino-1MQ is held to a ≥ 99% HPLC purity standard with a Certificate of Analysis available per batch. Reconstitute with bacteriostatic water and store refrigerated; handle strictly for research. See reconstitution & storage.

5-Amino-1MQ vial — research-grade detail

Frequently asked questions

What is 5-Amino-1MQ?

5-Amino-1MQ is a synthetic small molecule built on a methylquinolinium (quinoline-derived) scaffold; it is a chemical entity, not a peptide. It was characterized in the published literature as a selective, cell-permeable inhibitor of nicotinamide N-methyltransferase (NNMT). It is described and supplied as a research-use-only reference/tool compound and has no approved human therapeutic status.

Is 5-Amino-1MQ research use only?

Yes. 5-Amino-1MQ is supplied strictly for laboratory research — not for human or veterinary use, and not as a drug, food, or supplement.

Does Banger Labs provide a COA for 5-Amino-1MQ?

Yes — a Certificate of Analysis (HPLC purity + mass-spec identity) is available per batch on request. See the COA Library.

References

  1. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice — PubMed Central (Neelakantan et al., Biochemical Pharmacology, 2017)
  2. Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes — PubMed Central (Liu et al., BioMed Research International, 2021)
  3. Quinoline derived small molecule inhibitors of nicotinamide N-methyltransferase (NNMT) and uses thereof — Google Patents — USPTO Patent No. US11401243B2

Sources are provided for scientific reference and describe laboratory/preclinical research; they do not constitute medical advice or efficacy claims.

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By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Not a drug, food, or cosmetic. Educational information, not medical advice.