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Adipotide vs AOD-9604: Research Comparison (2026)

By the Banger Labs Research Team · Updated June 2026

Adipotide vs AOD-9604 research peptides

Short answer: Adipotide is a synthetic peptidomimetic studied in preclinical research as a tool for targeting the vasculature of white adipose tissue. It is intended for laboratory research use only and is not approved for human or therapeutic use. AOD-9604 is a synthetic peptide corresponding to the C-terminal region (residues 176-191) of human growth hormone, studied in preclinical research models in the context of lipid metabolism. This material is intended for research use only and is not approved for human or therapeutic use. They are compared below by class, mechanism, and research context.

Adipotide vs AOD-9604 at a glance

Attribute Adipotide AOD-9604
Class Synthetic proapoptotic peptidomimetic (vascular-homing peptide conjugate) Synthetic C-terminal fragment (hexadecapeptide) of human growth hormone
Primary research area Studied in preclinical rodent models as a probe of white adipose tissue vascular targeting Studied in rodent and in vitro models in the context of adipose-tissue lipid metabolism (lipolysis/lipogenesis signaling)
Purity standard ≥ 99% HPLC ≥ 99% HPLC
Use Research use only Research use only
Adipotide — research illustration

What is Adipotide?

Adipotide (also designated prohibitin-targeting peptide 1 / FTPP) is a synthetic peptidomimetic with the sequence CKGGRAKDC-GG-D(KLAKLAK)2, joining a cyclic vascular-homing motif to a proapoptotic moiety. It was first described by Kolonin and colleagues (2004) and is characterized in the literature strictly as a preclinical research compound, not an approved drug.

AOD-9604 — research illustration

What is AOD-9604?

AOD-9604 is a synthetic peptide derived from the C-terminal region of human growth hormone, corresponding to residues 176-191, with a tyrosine substituted for the phenylalanine at the N-terminal position. It is a 16-amino-acid peptide (hexadecapeptide) and, in published studies, has been characterized as not binding the growth hormone receptor or inducing IGF-1 production. It is supplied strictly as a research-use-only compound and is not an approved drug; its name historically derives from the abbreviation ‘AOD’ used during early research.

Adipotide research setting

How they differ

In published animal-model studies, the cyclic CKGGRAKDC domain is reported to bind a prohibitin / annexin A2 (ANXA2) receptor pair described on the endothelial cell surface of blood vessels supplying white adipose tissue. Following receptor-mediated internalization, the appended D(KLAKLAK)2 amphipathic domain is described as disrupting mitochondrial membranes and triggering apoptosis in those targeted endothelial cells. This mechanism has been characterized in rodent and non-human primate research models only. By contrast, In preclinical models, AOD-9604 has been studied in connection with adipose-tissue lipid metabolism, with research describing effects on lipolysis and lipogenesis signaling. Work in obese and beta-3 adrenergic receptor (beta3-AR) knockout mice (Heffernan et al., Endocrinology 2001) reported that the lipolytic activity observed in those models was associated with the beta-3 adrenergic receptor pathway rather than the classical growth hormone receptor. These are mechanistic observations from animal and in vitro research only and do not describe human outcomes.

AOD-9604 research setting

These describe laboratory/preclinical research only. No therapeutic, medical, or efficacy claims are made.

Frequently asked questions

Are Adipotide and AOD-9604 the same?

No — see the comparison table above; they differ in class and the research contexts in which they are studied.

Are these research use only?

Yes. Both are supplied strictly for laboratory research — not for human or veterinary use.

References

  1. Reversal of obesity by targeted ablation of adipose tissue — Kolonin et al., Nature Medicine 2004 (PMID 15133506)
  2. A Peptidomimetic Targeting White Fat Causes body-weight research and Improved Insulin Resistance in Obese Monkeys — Barnhart et al., Science Translational Medicine 2011 (PMID 22072637, PMCID PMC3666164)
  3. Prohibitin-targeting peptide 1 — Wikipedia (overview/structure reference)
  4. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice — PubMed (Endocrinology, 2001; PMID 11713213)
  5. AOD9604 — Wikipedia (overview with primary-source references)

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By the Banger Labs Research Team. For research use only. Not for human or veterinary use. Educational information, not medical advice.